Pentoxifylline

Pentoxifylline

Pentoxifylline (INN, BAN, USAN) or oxpentifylline (AAN) is a drug used to treat muscle pain in people with peripheral artery disease. It is generic and sold under many brand names worldwide.

pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA,inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. In addition, pentoxifylline improves red blood cell deformability (known as a haemorrheologic effect), reduces blood viscosity and decreases the potential for platelet aggregation and thrombus formation. Pentoxifylline is also an antagonist at adenosine 2 receptors.